By Nancy E. Lane (auth.), Nancy E. Lane (eds.)
In Aids hypersensitivity and Rheumatology, scientific specialists survey the newest info on hand at the key rheumatic and allergic matters that physicians face in treating the HIV-infected sufferer. Their articles specialise in the rheumatologic and dermatologic manifestations of HIV-1 an infection, which come with arthritis, myopathies, vasculitis, sicca syndrome, different autoimmune phenomena, and psoriasis. in addition they learn the query of allergies in HIV sufferers, together with drug allergy, with particular cognizance given to hostile reactions to trimethoprim-sulfamethoxazole, the main usually prescribed anti-infective. functional suggestion for the prognosis and remedy of those difficulties is given in complete.
Aids allergic reaction and Rheumatology deals physicians a complete advisor to the analysis and remedy of the allergic, immunologic, and rheumatic issues in HIV sufferers. Authoritative and practice-oriented, the ebook is destined to turn into a regular source for all these treating AIDS sufferers today.
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Additional resources for AIDS Allergy and Rheumatology
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In some cases, these viruses may be a factor in the pathogenesis of vasculitis in HIV-infected patients (2). Three patients with AIDS who had cytomegalovirus-induced necrotizing vasculitis have been described (105,106). On the other hand, HIV antigens may be involved in the formation of antigen-antibody complexes causing vasculitis in a manner similar to that of hepatitis B surface antigen. Immunofluorescent studies performed in two cases of leukocytoclastic vasculitis occurring in HIV-infected individuals gave some indication of such immune complex mechanisms (103).
The IgMs reactive with "i" antigen exhibited high-affinity and avidity, and additional reactivity with other common auto antigens could not be demonstrated. The VH genes of these five lymphoma associated IgMs were ~95% homologous to their germline VH genes of origin, and all five had significant nucleotide changes occurring in a pattern consistent with a somatic hypermutation process, suggesting that these clones may have been antigen-selected. In summary, HIV-I-infection is associated with widespread abnormalities in the host immune system, some of which are reflected in the numerous B-cell abnormalities discussed in this chapter.
AIDS Allergy and Rheumatology by Nancy E. Lane (auth.), Nancy E. Lane (eds.)