By Professor Thomas Unger, Professor Bernward A. Schölkens (auth.)
Nearly thirty years in the past, in 1974, the amount on Angiotensin edited via Irvine H.Page and F. Merlin Bumpus increased the guide of Experimental Pharmacology. Even after twenty years the multiplicity of its activities seems to be to not were absolutely stumbled on. to name cognizance to its many capabilities is among the reasons of this e-book. This new version of the amount on Angiotensin makes an attempt to supply an up to date account of the information and findings collected because the complexity of angiotensin was once so appropriately recognized.
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42 43 44 44 47 48 49 51 52 Abstract Extracellular matrix (ECM) is an important structural and functional constituent of both healthy and diseased blood vessels. Vascular cells are embedded in the multicomponent network of the ECM that contains collagens, other glycoproteins, proteoglycans and carbohydrates.
Circulation 103:448-454 Yusuf S (2002) From the HOPE to the ONTARGET and the TRANSCEND studies: challenges in improving prognosis. Am J Cardiol89 [Suppl]:18A-26A Yusuf S, Pepine q, Garces C et al (1992) Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions. Lancet 340:1173-1178 Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G (2000) Effects of an angiotensin -converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients.
In various animal models, it was conclusively shown that the RAS contributes to plaque development. In fact, infusion of angiotensin II in apoE-deficient mice exacerbated experimental atherosclerosis and blockade of AT! receptors by losartan blunted atherosclerotic plaque formation in monkeys (Strawn et al. 2000; Weiss et al. 2001). Molecular and cellular mechanisms, however, remained to be determined. 3 Angiotensin 11, Superoxide Anions and Inflammation Reactive oxygen species-generated by the membrane-bound NADPH oxidase system and stimulated by ANG II via the AT!
Angiotensin Vol. II by Professor Thomas Unger, Professor Bernward A. Schölkens (auth.)