By Alan Ebringer
Ankylosing spondylitis and Klebsiella is a complete and informative textual content at the reason behind Ankylosing spondylitis. Ankylosing spondylitis (AS) is a which impacts 20 million humans around the world and is probably going triggered or initiated through a bowel an infection from Klebsiella bacteria.
When a sufferer is contaminated by way of Klebsiella bacteria, his or her immune process will make antibodies opposed to the entire antigens or molecules present in the microbe. simply because a number of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but additionally the self tissues corresponding to the joints and the cells having an analogous HLA molecules, that's how the ailment AS begins. this is often the idea that of molecular similarity or “molecular mimicry” which formerly has been stumbled on to paintings in different autoimmune ailments; rheumatic fever and rheumatoid arthritis.
The first paper in this topic used to be released in 1976 and because thenover a hundred papers on rheumatological issues were released, from Prof Ebringer’s team, on the department of lifestyles Sciences, King’s collage in London, united kingdom.
The suitable details from those papers is extracted and offered during this e-book structure making it available to well-being execs, learn associations, pharmaceutical businesses and universities and most of the people.
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Extra resources for Ankylosing spondylitis and Klebsiella
3). 4. 02) extracts, and these differences are statistically significant when compared to serum obtained from the same rabbit before immunisation. Furthermore, serum from rabbit A agglutinated human blood group red cells coated with an ultrasonicate preparation of Enterobacter aerogenes to a titre of 1,024, whilst serum from the same rabbit obtained before immunisation gave a titre of 16. Similar preparations of Klebsiella pneumoniae could not be coated on to sheep, rabbit or human red blood cells.
Not surprisingly, the HLA results showed no predominant feature and were very disappointing to us. The fact that the two samples from ankylosing spondylitis patients had HLA-B27 held no message for us at the time. I next remember mentioning my quest for a disease having a familial tendency with a rheumatological background to my colleague Professor John Hobbs, who immediately remarked “Why not have a word with Dr. Derrick Brewerton, I am sure he will be interested”. A. 1007/978-1-4471-4300-0_3, © Springer-Verlag London 2013 15 16 3 The Discovery of HLA-B27 in Ankylosing Spondylitis and Related Disorders Dr.
HLA-B27 in reactive arthritis following infection. Ann Rheum Dis. 1975;34 Suppl 1:29–30. Boyum A. Separation of white blood cells. Nature. 1968;204:793–4. Crowle AJ. Immunodiffusion. London: Academic; 1961. References 33 Greenwood FC, Hunter WM, Glover JS. The preparation of 131I-labelled human growth hormone of high specific radioactivity. Biochem J. 1963;89:114–23. Staub AM. Preparation of cell wall antigens from Gram-negative bacteria. In: Williams CA, Chase MW, editors. Methods in immunology and immunochemistry, vol.
Ankylosing spondylitis and Klebsiella by Alan Ebringer