By Y. Becker (auth.), Yechiel Becker, Julia Hadar (eds.)
Research on antiviral medicinal drugs and their mode of motion in contaminated cells. in animals and in guy. has resulted in a greater realizing of the molecular seasoned cesses taken with virus replication. Screeninq of enormous numbers of traditional and semisynthetic compounds ended in the characterization of yes sub stances that had a constrained potency as antiviral druqs. a number of chemically synthesized compounds have been additionally came upon to be potent as antiviral brokers within the chemotherapy of human virus illnesses. an incredible trouble within the strengthen ment of potent antiviral brokers has been the inability of selectivity. and toxicity for uninfected cells. of gear that successfully inhibited virus replication in vitro. additional knowing of the molecular approaches of virus replication in contaminated cells has ended in the improvement of latest antivirals directed at virus-coded enzymes or proteins. fresh experiences on antivirals which are activated through the herpes simplex virus variety l-coded thy midine kinase from a prod rug to an antiviral drug have opened new instructions within the improvement of powerful antiviral medications. the current ebook offers with a few antiviral medications powerful opposed to herpes simplex viruses and gives a few perception into the molecular points of virus replication. It additionally throws mild at the new techniques to the advance of antiviral medicinal drugs. The molecular foundation of the antiviral job of latest and identified medicinal drugs and their attainable use in chemotherapy of viral sickness are awarded during this book.
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Additional info for Antiviral Drugs and Interferon: The Molecular Basis of Their Activity
If comparable results are obtained in humans, this combination should eliminate the problem of fluid overload in treatment of herpetic encephalitis. Both EHNA and DCF have been shown to potentiate the antiviral activity of araA in cultured cells and in animals. However, as discussed above, there are several reasons to believe that EHNA may be the better suited of the two for use in combination with araA. tion of ADA. EHNA produces a more rapid and controllable inhibi- Inhibition of ADA by EHNA is readily reversible, whereas inhibi- tion of this enzyme by DCF is not.
And Rapp, F. Antimicrob. Agents Chemotherapy ~:92-97, 1979. K. and Ribecky, R. Antimicrob. Agents Chemotherapy ~:101-110, 1979. 37 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. , Strickland, S. C. Ann. Y. Acad. Sci. C. H. Invest. Opthalmol. li:470-478, 1976. C. H. Proc. Soc. Exp. BioI. Med. ~:9296, 1977. S. H. J. Infect. Diseases lil:575-579, 1980. , Stebbing, N. H. , ~:393-404, 1981. S. H. A:3491-3494, 1980. T. H. J. Gen. Virol. ~:481-492, 1974. S. H. J.
Structures of the aranucleosides are shown in Figure 1. Following the discovery of 1- S-D-arabinofuranosylthymine (araT) and 1- S-Darabinofuranosyluracil (araU) in the sponge Cryptotethya crypt a (3), chemical syntheses of araC (4) and of araA (5) were reported. AraA was later produced as a fermentation product of Streptomyces antibioticus by Parke, Davis and Co. The corresponding nucleotides of araC and araA (5' mono-, di-, and triphosphates) were synthesized by Cohen and his colleagues (6-8).
Antiviral Drugs and Interferon: The Molecular Basis of Their Activity by Y. Becker (auth.), Yechiel Becker, Julia Hadar (eds.)