By Myrtle A. Davis
Univ. of Maryland, Baltimore. Discusses laser scanning cytometry for the research of apoptosis, tissue-based tools of quantification for reviews utilizing animal versions, and useful assays and ELISA strategies. DNLM: Apoptosis--physiology.
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Additional resources for Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification
Biol. Med. 22(1-2), 93–100. 47. Makrigiorgos, G. M. (1997) Detection of lipid peroxidation on erythrocytes using the excimer- forming property of a lipophilic BODIPY fluorescent dye. J. Biochem. Biophys. Methods 35(1), 23–35. 48. , Kassis, A. , and Makrigiorgos, G. M. (1998) Fluoresceinated phosphoethanolamine for flow-cytometric measurement of lipid peroxidation. Free Radic. Biol. Med. 25(6), 645–653. 49. , Simpson, A. , and Pozzan, T. (1992) Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin [published erratum appears in Nature 1992 Dec 24–31; 360(6406):768].
Cytometry 20(2), 162–171. 64. Leers, M. , et al. (1999) Immunocytochemical detection and mapping of a cytokeratin 18 neo- epitope exposed during early apoptosis. J. Pathol. 187(5), 567–572. 65. Morsi, H. , Leers, M. , Kabarity, H. , and Jager, W. (2000) Apoptosis, bcl-2 expression, and proliferation in benign and malignant endometrial epithelium: An approach using multiparameter flow cytometry. Gynecol Oncol. 77(1), 11–17. Apoptotic Cell Death 35 66. , Ramaekers, F. , and Reutelingsperger, C. P.
Analysis of Apoptosis by LSC 37 3 Analysis of Apoptosis by Laser-Scanning Cytometry Zbigniew Darzynkiewicz, Elzbieta Bedner, and Piotr Smolewski 1. INTRODUCTION One of the major goals in applications of cytometry in analysis of apoptosis is to identify and quantify dead cells and often to discriminate between apoptosis and necrosis. Recognition of dead cells relies on the presence of a particular biochemical or molecular marker that is characteristic for apoptosis, necrosis, or both. A variety of methods have been developed, especially for the identification of apoptotic cells (see reviews in refs.
Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification by Myrtle A. Davis