By Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor
The latest, accomplished, and authoritative pharmacology textual content in healthiness medicine
Enhanced by means of greater than 300 illustrations -- many in complete color
Organized to mirror the syllabi in lots of pharmacology classes and in built-in curricula, Basic & scientific Pharmacology, 12e covers the real innovations scholars want to know concerning the technological know-how of pharmacology and its program to medical perform. collection of the subject material and order of its presentation are in line with the authors’ a long time adventure in instructing this fabric to hundreds of thousands of clinical, pharmacy, dental, podiatry, nursing, and different future health technology students.
To be as clinically correct as attainable, the booklet comprises sections that in particular deal with the medical selection and use of gear in sufferers and the tracking in their results, and case experiences that introduce scientific difficulties in lots of chapters. provided in complete colour and more advantageous via greater than 300 illustrations, Basic & medical Pharmacology gains a number of precis tables and diagrams that encapsulate vital information.
Coverage that spans each point of clinical pharmacology:
- uncomplicated rules
- Autonomic medicines
- Cardiovascular-renal medicinal drugs
- medications with vital activities on delicate muscular tissues
- important fearful method medicinal drugs
- medicinal drugs used to regard anemias, clotting problems, hyperlipidemia, and irritation and gout
- Endocrine medications
- Chemotherapeutic and immunologic medications
- targeted topics (perinatal, geriatric, and dermatologic pharmacology)
- Botanical and "food supplements," and over the counter medicines
Also during this edition:
- Drug precis Tables finish such a lot chapters, offering a concise precis of an important medicines
- normal suggestions when it comes to newly came upon receptors, receptor mechanisms, and drug transporters
- Descriptions of vital new medications, together with monoclonal antibodies
Read Online or Download Basic and Clinical Pharmacology 12/E PDF
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Additional resources for Basic and Clinical Pharmacology 12/E
This “desensitization” is often rapidly reversible; a second exposure to agonist, if provided a few minutes after termination of the first exposure, results in a response similar to the initial response. 26 SECTION I Basic Principles TABLE 2–1 G proteins and their receptors and effectors. G Protein Receptors for Effector/Signaling Pathway Gs β-Adrenergic amines, glucagon, histamine, serotonin, and many other hormones ↑ Adenylyl cyclase →↑ cAMP Gi1, Gi2, Gi3 α2-Adrenergic amines, acetylcholine (muscarinic), opioids, serotonin, and many others Several, including: ↓ Adenylyl cyclase →↓ cAMP + Open cardiac K channels →↓ heart rate Golf Odorants (olfactory epithelium) ↑ Adenylyl cyclase →↑ cAMP Go Neurotransmitters in brain (not yet specifically identified) Not yet clear Gq Acetylcholine (muscarinic), bombesin, serotonin (5-HT2), and many others ↑ Phospholipase C →↑ IP3, diacylglycerol, cytoplasmic Ca2+ Gt1, Gt2 Photons (rhodopsin and color opsins in retinal rod and cone cells) ↑ cGMP phosphodiesterase →↓ cGMP (phototransduction) cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate.
Other Mechanisms of Drug Antagonism Not all the mechanisms of antagonism involve interactions of drugs or endogenous ligands at a single type of receptor, and some types of antagonism do not involve a receptor at all. For example, protamine, a protein that is positively charged at physiologic pH, can be used clinically to counteract the effects of heparin, an anticoagulant that is negatively charged. In this case, one drug acts as a chemical antagonist of the other simply by ionic binding that makes the other drug unavailable for interactions with proteins involved in blood clotting.
Increased cGMP concentration causes relaxation of vascular smooth muscle by a kinase-mediated mechanism that results in dephosphorylation of myosin light chains (see Figure 12–2). In these smooth muscle cells, cGMP synthesis can be elevated by two transmembrane signaling mechanisms utilizing two different guanylyl cyclases. Atrial natriuretic peptide, a blood-borne peptide hormone, stimulates a transmembrane receptor by binding to its extracellular domain, thereby activating the guanylyl cyclase activity that resides in the receptor’s intracellular domain.
Basic and Clinical Pharmacology 12/E by Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor