By Bertram G. Katzung
The most modern, authoritative, and entire pharmacology ebook for scientific, pharmacy, and different healthiness technology scholars. broadly revered for its readability, comprehensiveness, and association, this pharmacology path publication offers the fundamental recommendations that scholars want to know in regards to the technology of pharmacology and their software. specializes in the elemental rules of every drug crew in addition to the medical selection and use of substances in sufferers and the tracking in their results.
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Additional resources for Basic & Clinical Pharmacology, Ninth Edition
In this way, cAMP, Ca2+, or other second messengers can use the presence or absence of particular kinases or kinase substrates to produce quite different effects in different cell types. Inhibitors of protein kinases have great potential as therapeutic agents, particularly in neoplastic diseases. Trastuzumab, an antibody that antagonizes growth factor receptor signaling, was discussed earlier as a therapeutic agent for breast cancer. Another example of this general approach is imatinib (Gleevec, STI571), a small molecule inhibitor of the cytoplasmic tyrosine kinase Bcr/Abl, which is activated by growth factor signaling pathways and is overexpressed in chronic myelogenous leukemia (CML).
Maximal Efficacy This parameter reflects the limit of the dose-response relation on the response axis. Drugs A, C, and D in Figure 2–15 have equal maximal efficacy, while all have greater maximal efficacy than drug B. The maximal efficacy (sometimes referred to simply as efficacy) of a drug is obviously crucial for making clinical decisions when a large response is needed. It may be determined by the drug's mode of interactions with receptors (as with partial agonists, described above)* or by characteristics of the receptor-effector system involved.
8 50 ng/mL ... 9 ... 9 20 ng/mL ... Pyridostigmi 14 ne 85 ... 9 75 ng/mL ... 1 100 ng/mL ... Rifampin ? 5 ... 32 15 10 ... 4 125 14 2 ng/mL ... 2 105 11 ... 1 10 mg/L >20 mg/L Tobramycin ... 2 ... 8 210 14 10 mg/L ... 9 100 mg/L ... Trimethopri m 100 69 44 9 130 11 ... Tubocurarine . . 6 mg/L ... 1 14 75 mg/L >150 mg/L Vancomycin . . 6 ... Verapamil 3 90 63 350 4 ... 8 37 ... 1 ... 6. 2 Varies with concentration. 3 Target area under the concentration time curve after a single dose. 4 Can be estimated from measured Cp using CL = Vmax/(Km + Cp); Vmax = 415 mg/d, Km = 5 mg/L.
Basic & Clinical Pharmacology, Ninth Edition by Bertram G. Katzung